Intrinsic Fluorescence Correction

Advanced Glycation End Product Detection

Until recently, skin AGEs had no practical value as a commercial test because their measurement involved a punch biopsy (typically large enough to require a stitch) of the skin, and a complicated assay that could only be performed by a few academic laboratories. AGEs have a robust optical signature that can be detected and measured via spectroscopic analysis. However, prior to the development of proprietary spectroscopic detection technology by VeraLight, no one had determined how to normalize this signature for variations in skin color, blood content and structure, which prevented its practical use as an accurate, reproducible screening test.

Collagen, the main protein of skin and connective tissue, readily undergoes glycation resulting in AGE formation. VeraLight's technology employs quantitative fluorescence spectroscopy to non-invasively measure collagen cross-links and other fluorescent AGE that can be correlated to a quantitative risk score for prediabetes or type 2 diabetes. VeraLight's technology uses various wavelengths of near ultraviolet and blue light that illuminate the subject's skin. The illumination excites electrons in the collagen-linked AGE and causes them to emit light that is measured by SCOUT DS®.